Of box lengths from either end of the box. #: p <0.Sato
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Of box lengths from either end of the box. #: p tert-Butyl (2-bromothiazol-5-yl)carbamate lengths from either end of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/14960617 the box. #: p 1-((tert-Butyldimethylsilyl)oxy)propan-2-ol of TAT and SFMC during CPB. A total of 720 mL of fresh frozenABFig. 4 Comparison of soluble fibrin monomer complex (SFMC) between the groups. a: SFMC at the start of cardiopulmonary bypass (CPB) (1), at 1 h from the start of CPB (2), and at the end of CPB (3). b: The increase in SFMC during CPB. (open column): valve surgery; (closed column): aortic replacement surgery; x: outlier; Data are showed as box and whisker plots (25 and 75 percentiles, outliers). Outliers are showed as cases with values more than 1.5 times of box lengths from PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25116583 either end of the box. #: p < 0.05. No significant difference in the increase in SFMC during CPB was detected between the groupsSato et al. Journal of Cardiothoracic Surgery (2015) 10:Page 6 ofAB600 500CPBCPB50(1)(2)(3)(4)(5)(6)(7)(8) (9) (10) (11) (12) (13) (14) (15)Fig. 5 Time courses of coagulation markers during surgery in the representative case of each group. a: valve surgery; b: aortic replacement surgery. (closed column): thrombin ntithrombin complex (ng/mL); (open column): soluble fibrin monomer complex (g/mL). CPB time is shown by the gray zone. (1) and (7): pre-operation; (2) and (8): pre-CPB; (3) and (9): the start of CPB; (4) and (10): 1 h after the start of CPB; (5) and (13): the end of CPB; (6) and (15): post-operation; (11): 2 h after the start of CPB; (12): 3 h after the start of CPB; (14): 1 h after the end of CPBplasma was transfused to prevent progressing hypofibrinogenemia, resulting in diminished reduction of the fibrinogen level (Fig. 5b).Discussion Cardiovascular surgery using CPB decreases the plasma concentration of coagulation factors, including fibrinogen, primarily by hemodilution with CPB priming and intravenous fluids [7]. Thoracic aortic replacement surgery is frequently accompanied by massive hemorrhage due to severe hypofibrinogenemia [8]. A recent report showed that fibri.
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